VISDB - VIS Detail

Basic Information

VIS ID

TVIS44001531

Fusion event

HTLV-1-GXYLT1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr12

Cytoband

q12

Reference genome

GRCh37/hg19

Start

42525910/42132108 (Hg38)

End

42525910/42132108 (Hg38)

Orient

Location type

Intronic

Target gene

GXYLT1

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-33a-5p ; hsa-mir-99a-5p ; hsa-mir-3180-5p ; hsa-mir-3182 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-9-3p ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-2115-5p ; hsa-mir-516a-3p ; hsa-mir-4729 ; hsa-mir-545-5p ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-4429 ; hsa-mir-320a ; hsa-mir-568 ; hsa-mir-340-5p ; hsa-mir-4756-3p ; hsa-mir-5582-5p ; hsa-mir-4484 ; hsa-mir-6768-3p ; hsa-mir-203a-3p ; hsa-mir-548an ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-4445-5p ; hsa-mir-508-3p ; hsa-mir-6766-3p ; hsa-mir-548c-3p ; hsa-mir-4782-3p ; hsa-mir-219a-5p ; hsa-mir-7856-5p ; hsa-mir-3658 ; hsa-mir-5701 ; hsa-mir-944 ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-506-3p ; hsa-mir-885-5p ; hsa-mir-4698 ; hsa-mir-3675-3p ; hsa-mir-4303 ; hsa-mir-4682 ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p ; hsa-mir-193b-3p ; hsa-mir-193a-3p

Nearest miRNA

hsa-mir-1244-3/Upstream/16258029; hsa-let-7i/Downstream/191592;

Nearest TSS

ENST00000382841/Upstream/199516; ENST00000551658/Downstream/12604;

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/558435, chr12-CpG: 92/Downstream/12215

Upstream sequence

CAACAGTGAAACATGGAAATAGAAATCTCAAAAACAAATTCaatttttctataaaattaattaaaattatatatatttaaCAATACCATTTGCAGCCTCA

Downstream sequence

ACTTGTACTTTAAGTTACAAAACAAATCAGTTATGTGTtgttttccaaacctgcctggtcctcaggtcacttgttaaaaatacagatataggatcctatc

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.