Basic Information
VIS ID
TVIS44001532
Fusion event
HTLV-1-USP7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
8990504/8896647 (Hg38)
End
8990504/8896647 (Hg38)
Orient
-
Location type
Intronic
Target gene
USP7
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-935 ; hsa-mir-877-3p ; hsa-mir-615-3p ; hsa-mir-26a-5p ; hsa-mir-3676-3p
Nearest miRNA
hsa-mir-1225/Upstream/3264081; hsa-mir-11401/Downstream/2409793;
Nearest TSS
ENST00000527434/Upstream/13949; ENST00000564485/Downstream/607;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/27567, chr16-CpG: 62/Downstream/56892
Upstream sequence
AGCCCAAATGTTGGCTAGATGGAACAGAAGTGACTCAATCTGTCAAATACAAAATCAGGAGTCACCCCTTCCAGTTTCAGTTCATCGTTCAAATGGAATC
Downstream sequence
GTATCCTTCCTCTGTTTGGCTTTTCTATGGGAACTGCGCCTTTTTACTACAGCTAATGTTATCAGAAGATACAAGGGGAAGGAGGAAAAACGTGGCTTAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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