Basic Information
VIS ID
TVIS44001533
Fusion event
HTLV-1-PPP2R2C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
6491976/6490249 (Hg38)
End
6491976/6490249 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
PPP2R2C
miRNAs that regulate target gene
hsa-mir-142-3p
Nearest miRNA
hsa-mir-378d-1/Upstream/566921; hsa-mir-12113/Downstream/820201;
Nearest TSS
ENST00000502981/Upstream/17803; ENST00000504960/Downstream/33298;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/17442, chr4-CpG: 138/Downstream/72775
Nearest cancer related gene
PPP2R2C(TSG, No orient, 0)
Upstream sequence
CCTGATGCTCATCCCCACCTCCCACCTGGGCCTGGCCATGTCAGGAAAACAAGACTCCAAGCCTTTTGTGGGCAGGTTCCTGGGAGCGCTCATCTGGGAC
Downstream sequence
TTATGTCCTCCATCTATAAAGGGACTGCAGGGAATGAACTCTACCCAGCCTTCAGCAGGGAGATGGCATTCATCTTTCCCACTGGCATTTCCAAGCCATC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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