Basic Information
VIS ID
TVIS44001534
Fusion event
HTLV-1-FBXL17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
107716131/108380430 (Hg38)
End
107716131/108380430 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
FBXL17
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-186-3p ; hsa-mir-548p ; hsa-mir-548b-3p ; hsa-mir-330-3p
Nearest miRNA
hsa-mir-10397/Upstream/7563865; hsa-mir-103a-1/Downstream/2133399;
Nearest TSS
ENST00000502646/Upstream/12476; ENST00000513676/Downstream/533;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/707940, chr5-CpG: 220/Downstream/178
Upstream sequence
TTCAAACACCAACATGCAAAGCCTTTACCCACTAAGTATAAATTCCTCGATTAAAAAATTTTTTTTTCCACAGAATACCTGCGAAGTTTCTAAACCACTG
Downstream sequence
GGTTGGGATTCTAATAATAGCTGAACCCTGAATGGTGGGTTATAGAGTCAAGCTATTAAAAGACATTCAGTAGACTCCAAGTGCTCCTACTTCAAAAAAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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