Basic Information
VIS ID
TVIS44001537
Fusion event
HTLV-1-chr4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
58790432/57924266 (Hg38)
End
58790432/57924266 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4B
Nearest miRNA
hsa-mir-12113/Upstream/5211519; hsa-mir-1243/Downstream/2998353;
Nearest TSS
ENST00000502981/Upstream/204231; ENST00000513836/Downstream/612062;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/728317, chr4-CpG: 222/Downstream/3275899
Upstream sequence
tgtatacatatgtaactaacctgcacattgtgcacatgtaccttaaatcttaaagtataaaaaaaaaaaCAATGGGGAGGGTTCTGAGGGGACGAAGCAC
Downstream sequence
AGCAGGTCTATCACCCTTTTTATCTAATATCTCCTTTTCTAATCACAAGCACTTAAATTCTTCACCATTGCCAGAACCGTAAACAATATGAGAGATGGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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