Basic Information
VIS ID
TVIS44001544
Fusion event
HTLV-1-DGAT2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.5
Reference genome
GRCh37/hg19
Start
75488561/75777516 (Hg38)
End
75488561/75777516 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
DGAT2
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-203a-3p ; hsa-mir-320e ; hsa-mir-4511 ; hsa-mir-3133 ; hsa-mir-4316 ; hsa-mir-3188 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-2467-5p ; hsa-mir-3975 ; hsa-mir-605-3p ; hsa-mir-3664-3p ; hsa-mir-873-5p ; hsa-mir-5582-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-10392/Upstream/442330; hsa-let-7a-2/Downstream/3624506;
Nearest TSS
ENST00000527297/Upstream/8515; ENST00000605099/Downstream/6880;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/8389, chr11-CpG: 16/Downstream/37150
Upstream sequence
tattttacccatcaaacaggagaggacaccgaggcttaCTTGGTAATTAATCAGcattcatagagatctttactttttatgaagctcttggctatacatt
Downstream sequence
atctcatttaattcccacaacaatctggtgaggtaggtattagccccactgtatagatgaggaagctgaagcttgtataggaagtgactcatccaggcca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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