Basic Information
VIS ID
TVIS44001545
Fusion event
HTLV-1-MIRLET7BHG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
46484615/46088735 (Hg38)
End
46484615/46088735 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA22A
Target gene
MIRLET7BHG
Nearest miRNA
hsa-mir-1249/Upstream/328137; hsa-let-7a-3/Downstream/2309;
Nearest TSS
ENST00000624155/Upstream/2732; ENST00000460086/Downstream/61786;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/2591, chr22-CpG: 23/Downstream/33839
Upstream sequence
GGTTTTTTTTTTCTAGGGAAAGAGTCATGGAATTTGACCAGAGATGATTGTTTGAGGGGCCAAGAGCCAGCCAGAGCCCACGGACATGCAGCATGGAAGG
Downstream sequence
TGTAGCCAGAAGCCTGGGCAGCGATACCCGCCGGTCCGCCTTGGCATCTGCTTGGCACCCAGTGACCTGGCTGTGAACACAGTGAGCGGAGGCAGGAAGT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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