Basic Information
VIS ID
TVIS44001548
Fusion event
HTLV-1-CNTNAP5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
125640791/124883214 (Hg38)
End
125640791/124883214 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CNTNAP5
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-210-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-4789-5p ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-466 ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-16-1-3p ; hsa-mir-1285-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-3680-5p ; hsa-mir-4798-3p ; hsa-mir-5580-3p ; hsa-mir-4643 ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/11161846; hsa-mir-10b/Downstream/2540323;
Nearest TSS
ENST00000437798/Upstream/661509; ENST00000430692/Downstream/827755;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/857536, chr2-CpG: 51/Downstream/1772906
Upstream sequence
ctagagtgcagtggcatgattttagtaacctgtgcctcccaggcttaagcagtcctcccacctcagcctctcaagtagctgggaagacaaggtcatactg
Downstream sequence
ccaagtacagctaatttttgtattttgtatagagatgggctttcaccatgttgcccgggctggtcttgaactcatgggctcaagcaatctatgtgtctca
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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