Basic Information
VIS ID
TVIS44001555
Fusion event
HTLV-1-ROR2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
94567929/91805647 (Hg38)
End
94567929/91805647 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROR2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-let-7f-5p ; hsa-mir-451a
Nearest miRNA
hsa-mir-101-2/Upstream/169286; hsa-let-7a-1/Downstream/486811;
Nearest TSS
ENST00000422679/Upstream/29866; ENST00000457003/Downstream/81552;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/72166, chr9-CpG: 21/Downstream/94636
Nearest cancer related gene
ROR2(TSG, No orient, 0)
Upstream sequence
TCTCCACATGAAAGCTGGAAATCTAAATCACACTCACCAACCTAAGGAGTGGCAGAGGAAGAAATGCCAGCGTGGCCTGGGCATGTCTTCATAGGATGGC
Downstream sequence
AGCAGAAGTACATGTacacacccatgcacatgctcacacacaagtatgaacatacgtacacacacccacacacacacatatgcacacCTTTCAACCCAAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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