Basic Information
VIS ID
TVIS44001558
Fusion event
HTLV-1-FN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
216277835/215413112 (Hg38)
End
216277835/215413112 (Hg38)
Orient
-
Location type
Intronic
Target gene
FN1
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-1-3p ; hsa-let-7g-5p ; hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-218-5p ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-10b/Upstream/1654953; hsa-mir-1244-1/Downstream/2487401;
Nearest TSS
ENST00000437798/Upstream/3162; ENST00000412951/Downstream/8158;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/100703, chr2-CpG: 43/Downstream/22432
Upstream sequence
AAGTTTCCAGAATCAAGGTTCAATGGAATTATTCCTCTTTGTTTTTATACCTTAATATTGCTGCATTTTAGTTTGCTTCGTATAGGAATTATTGCCTTAT
Downstream sequence
AATACACTTGGGGGttttttgaaacagaatctcgctctgttgcccaggctagggtgcaatggcgcgatcttggctcaactccctgcaacctttgcctcct
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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