Basic Information
VIS ID
TVIS44001577
Fusion event
HTLV-1-SIPA1L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
72103801/71637084 (Hg38)
End
72103801/71637084 (Hg38)
Orient
+
Location type
Intronic
Target gene
SIPA1L1
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-4531 ; hsa-mir-5581-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-539-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-208a/Upstream/4195154; hsa-mir-1185-1/Downstream/879736;
Nearest TSS
ENST00000550708/Upstream/18328; ENST00000554960/Downstream/48278;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/315576, chr14-CpG: 114/Downstream/294863
Upstream sequence
gggtcgcagtgagctgagatggcgccactgcactccagcctgagtgacagaatgagactccatctttaaaaaaaaaaaaaaaacagctacatctttgggg
Downstream sequence
tttaaaaaaaaattttttttttttcataaaacccagatcctgtgtgtgcacgcgtgcacacacacacacacacgctagatctttgaaaagatgataaaat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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