Basic Information
VIS ID
TVIS44001582
Fusion event
HTLV-1-CMSS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
99787428/100068584 (Hg38)
End
99787428/100068584 (Hg38)
Orient
+
Location type
Intronic
Target gene
CMSS1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-3163 ; hsa-mir-100-3p ; hsa-mir-4282 ; hsa-mir-548e-5p ; hsa-mir-1200 ; hsa-mir-2355-5p ; hsa-mir-6778-3p ; hsa-mir-6089 ; hsa-mir-5008-5p ; hsa-mir-4649-3p ; hsa-mir-486-5p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-5196-3p ; hsa-mir-4290 ; hsa-mir-4758-3p ; hsa-mir-4323 ; hsa-mir-4687-5p
Nearest miRNA
hsa-let-7g/Upstream/104186; hsa-mir-12124/Downstream/3455449;
Nearest TSS
ENST00000440867/Upstream/192381; ENST00000479555/Downstream/45680;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/192127, chr3-CpG: 22/Downstream/156676
Upstream sequence
aaatattcatacatcttgctataggaatattaatgttggattagtgggtgctgccaaagaacccactgcaagtttcatataatacatagtatatgtatca
Downstream sequence
gtttacttttctaaaacatgaaaaattctgaaACAATAGtttttttgttttttgtatttttgagactgagtcttgctctgttacccaggctggagtgcag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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