Basic Information
VIS ID
TVIS44001589
Fusion event
HTLV-1-STAC integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
36577287/36535795 (Hg38)
End
36577287/36535795 (Hg38)
Orient
-
Location type
Intronic
Target gene
STAC
miRNAs that regulate target gene
hsa-mir-4762-3p ; hsa-mir-3192-3p ; hsa-mir-6830-3p ; hsa-mir-185-3p ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-6828-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-4502
Nearest miRNA
hsa-mir-12127/Upstream/791236; hsa-let-7g/Downstream/1433609;
Nearest TSS
ENST00000440867/Upstream/7086; ENST00000476172/Downstream/194000;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/155077, chr3-CpG: 69/Downstream/228179
Upstream sequence
tgaaggccttttctgcatctattgaaataatcatgtggtttttgtctttagttctgtttatatgtgaattacatgtattgatttgcatatgttgaaccag
Downstream sequence
ccttgcatcccaagaatgaagccaacttgatcatggtgaataagctttttgatgtgctgctggattcagtttgccagtattttaccaaggatttttacat
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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