Basic Information
VIS ID
TVIS44001600
Fusion event
HTLV-1-SEPTIN9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
75455223/77459141 (Hg38)
End
75455223/77459141 (Hg38)
Orient
-
Location type
Intronic
Target gene
SEPTIN9
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-186-5p ; hsa-mir-10a-5p ; hsa-mir-5587-5p ; hsa-mir-670-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-4308 ; hsa-mir-216b-3p ; hsa-mir-4802-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-6500-3p ; hsa-mir-4717-3p ; hsa-mir-3614-5p ; hsa-mir-128-1-5p ; hsa-mir-128-2-5p ; hsa-mir-1914-3p ; hsa-mir-3144-5p ; hsa-mir-3184-5p ; hsa-mir-3191-3p ; hsa-mir-3677-3p ; hsa-mir-423-5p ; hsa-mir-4652-5p ; hsa-mir-4655-3p ; hsa-mir-4710 ; hsa-mir-491-5p ; hsa-mir-5194 ; hsa-mir-6734-5p ; hsa-mir-6738-5p ; hsa-mir-6781-5p ; hsa-mir-6795-3p ; hsa-mir-6804-5p ; hsa-mir-6810-5p ; hsa-mir-6826-3p ; hsa-mir-6882-3p ; hsa-mir-6887-3p
Nearest miRNA
hsa-mir-10226/Upstream/62087; hsa-mir-1250/Downstream/2248035;
Nearest TSS
ENST00000595228/Upstream/2775; ENST00000589920/Downstream/7262;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/7402, chr17-CpG: 59/Downstream/69366
Nearest cancer related gene
SEPTIN9(OG, No orient, 0)
Upstream sequence
AGGCAGTGAACGGGGCCACGGTCGGCCCCACACGTGGCACCACCAGCCCTGCTGAGCCTGCACCTGCTCCTCAGGCCCCCTGAGTGCCACTACCACCTGG
Downstream sequence
CACCCCTTGGTCTGATTCCTGCTTCCTGCCCGCCTGGGAAGAGTGAGACCACTTGCCTAAAGTCCCTTAGCTGTCCTTAACCATTCTGGCTGCCTCCTGG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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