Basic Information
VIS ID
TVIS44001605
Fusion event
HTLV-1-COQ8A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.13
Reference genome
GRCh37/hg19
Start
227167288/226979587 (Hg38)
End
227167288/226979587 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
COQ8A
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-101-1/Upstream/1057445; hsa-mir-1182/Downstream/962003;
Nearest TSS
ENST00000473358/Upstream/2183; ENST00000479852/Downstream/3420;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3051, chr1-CpG: 104/Downstream/338158
Upstream sequence
CCTCTGGAGTTCTGGGCCAAGTCCCCTGGCCCCGGCCCATTCAGGGAATGTCAGCTCATTCTGGTATCACGCCCTTCCACCCCCGTCCATGGGGACCCCC
Downstream sequence
AGAGACACCCAGTGTCTGGCCACACTGCAGCCCTCACAGCCCTGTCTTCCAGCCTGGGCTAGCCTCCTTTGGGGGCCCTGCCAGTCCCCGGACAGCCCCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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