Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene72305586719108187216175072099626721065047207862672083287720945107209604872097089720986007210738372108606720624287206357672069201720700007209880172099000720606917206088072108202
Basic Information
VIS ID
TVIS44001615
Fusion event
HTLV-1-NHSL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
71328052/72108202 (Hg38)
End
71328052/72108202 (Hg38)
Orient
-
Location type
Intronic
Target gene
NHSL2
miRNAs that regulate target gene
hsa-mir-577 ; hsa-mir-183-5p ; hsa-mir-4777-5p ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-4699-5p ; hsa-mir-517-5p ; hsa-mir-1245b-3p ; hsa-mir-654-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-562 ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-3115 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6832-3p ; hsa-mir-6779-3p ; hsa-mir-4687-5p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p
Nearest miRNA
hsa-let-7f-2/Upstream/2085279; hsa-mir-105-1/Downstream/2110175;
Nearest TSS
ENST00000429181/Upstream/28426; ENST00000510661/Downstream/23626;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/89377, chrX-CpG: 130/Downstream/22889
Upstream sequence
ggaacagatttgagagggagttaggaggtcagattgacaggtcttggtgatTCCTCAAGGTGGAAAGTAAAAACCGGGACCCAGTGGCACAGTGGTGTGC
Downstream sequence
AGTGTTATCCTAGCCATGGCAGTAGCTGCCCTTTGTTAAGGGTTCTGGAGCATTTGCAGTACTTGCCCTTACATTAACTCACCCCAGCCTCAAAGTCAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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