Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene44580520444272344452903844488501444909124449168444493843444680324446974844503877
Basic Information
VIS ID
TVIS44001619
Fusion event
HTLV-1-CTDSPL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
44796075/44503877 (Hg38)
End
44796075/44503877 (Hg38)
Orient
+
Location type
Intronic
Target gene
CTDSPL2
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-100-5p ; hsa-mir-374a-5p ; hsa-mir-18b-3p ; hsa-mir-3157-3p ; hsa-mir-4744 ; hsa-mir-4709-3p ; hsa-mir-3127-5p ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-4699-5p ; hsa-mir-539-5p ; hsa-mir-3918 ; hsa-mir-4761-3p ; hsa-mir-140-3p ; hsa-mir-618 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p
Nearest miRNA
hsa-mir-1233-1/Upstream/710118; hsa-mir-10393/Downstream/213967;
Nearest TSS
ENST00000557528/Upstream/6850; ENST00000559738/Downstream/13606;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/75937, chr15-CpG: 131/Downstream/32562
Upstream sequence
AGCCAGTCAGTGGCTTTCTGAAGATCAGTAAAATCAACAAACTTTGGGTCAGCTGTCCAGAAATCAGATTGTGGTAAGCACTCAAGGACAGATAGGATCC
Downstream sequence
CTGTAGGGAGCTACTTGTAAAAGATGCTTTGTTTTATTAGTAGAGGTTGCTTTTATGGGAAAAGTTGGGGGAAGAGGTGGATGGGGAAGGCCACGGTTAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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