Basic Information
VIS ID
TVIS44001621
Fusion event
HTLV-1-ZNF831 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
57723270/59148215 (Hg38)
End
57723270/59148215 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF831
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4470 ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-6865-3p ; hsa-mir-34b-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/329902; hsa-mir-1-1/Downstream/1160259;
Nearest TSS
ENST00000382410/Upstream/24811; ENST00000371030/Downstream/42805;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/105048, chr20-CpG: 114/Downstream/43126
Nearby gene
ZNF831(+42805) ;
Upstream sequence
ATTGACGCTAATTGTTAAGTGCCGTTGGTCAAGGCCAATGCATAGTCTTCGTTTAGTTCCTAAGTCATTTGTGGTCGGCCCATCCAAGACAGGGACACGG
Downstream sequence
ACAATCTCATCAGAGTAGGCTGGGAGGGTTTCCATGATGGAATGGGGCTGGCCTCTCTGTTGAGGGGGGATATCCAAGGGGTGCACATGAGCTCTGAGGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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