Basic Information
VIS ID
TVIS44001630
Fusion event
HTLV-1-PROS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
93604836/93885992 (Hg38)
End
93604836/93885992 (Hg38)
Orient
-
Location type
Intronic
Target gene
PROS1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-494-3p
Nearest miRNA
hsa-let-7g/Upstream/6659715; hsa-mir-12124/Downstream/2473972;
Nearest TSS
ENST00000440867/Upstream/4778316; ENST00000478400/Downstream/25165;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/4771035, chr3-CpG: 39/Downstream/87718
Upstream sequence
AGCTCTTGCATTTAAGTCCTAAAAATAGACTTGAGAAAGTCCTTTGACTGGCTTTTACAAAATGGTGTAATTTTGGACTTAAATATATGAATTTATATGT
Downstream sequence
TTAACAACTGAGTATGGATTATCATGATGTTAACACTGAACATTACATTACTAATGTTAACATTAGTGTTAACATTCTCAAGTGTTAACTTGAGAATTTT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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