Basic Information
VIS ID
TVIS44001635
Fusion event
HTLV-1-NCAM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
112856321/112985599 (Hg38)
End
112856321/112985599 (Hg38)
Orient
+
Location type
Intronic
Target gene
NCAM1
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-210-3p ; hsa-mir-200c-3p ; hsa-mir-375 ; hsa-mir-30a-5p ; hsa-mir-3148 ; hsa-mir-651-3p
Nearest miRNA
hsa-mir-10392/Upstream/1472084; hsa-let-7a-2/Downstream/464424;
Nearest TSS
ENST00000527297/Upstream/22139; ENST00000525973/Downstream/145095;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/21831, chr11-CpG: 34/Downstream/329011
Upstream sequence
agtatggacattttaacagtattaattctttcagtccatgaacatgggacatctttccatttatttgtgccttcttcaatttctttcatcaatgttgtgt
Downstream sequence
agttttctgtatacagatttttacctctttagttaagtttagtcctaagtattttataatttttgatgctattttaatgagattgtttttagatttcttt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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