Basic Information
VIS ID
TVIS44001636
Fusion event
HTLV-1-C12orf60 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
14859215/14706281 (Hg38)
End
14859215/14706281 (Hg38)
Orient
+
Location type
Intronic
Target gene
C12orf60
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-574-5p ; hsa-mir-297 ; hsa-mir-6867-5p ; hsa-mir-567 ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5579-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/1790363; hsa-let-7i/Downstream/2967018;
Nearest TSS
ENST00000382841/Upstream/9696; ENST00000544848/Downstream/63341;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/138122, chr12-CpG: 86/Downstream/63662
Nearby gene
GUCY2C(-9696) ;
Upstream sequence
ctaaatggaataacagaaggagaaaaacaggtataaaaggtctacgaattgggacgactcgacgtctgattagagagtgcttaaggagatttggcatagt
Downstream sequence
cctgccagcaaagattatttatttacttcaagagttaagagtggcagtttggggatagcaccaggagatatcagctgtgatggcttggaaaaacagtgta
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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