Basic Information
VIS ID
TVIS44001647
Fusion event
HTLV-1-WWOX integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
79199021/79165124 (Hg38)
End
79199021/79165124 (Hg38)
Orient
-
Location type
Intronic
Target gene
WWOX
Nearest miRNA
hsa-mir-1225/Upstream/2296105; hsa-mir-11401/Downstream/2219894;
Nearest TSS
ENST00000527434/Upstream/86890; ENST00000566103/Downstream/31235;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1064955, chr16-CpG: 44/Downstream/424470
Nearest cancer related gene
WWOX(TSG, No orient, 0)
Upstream sequence
CCTCTATTTGAGGGTCTCTGGGAGGACCATAGTTGTTTCTGAAGTATCACTTATCCTACGTTCCATGTAAGATCTCTTTCCTAGGGTAAACTTGATATGG
Downstream sequence
AAGGTCTTCACAGATTAAAACGAAGGAAAAAAAAAAAAAAAACTAGATAAATCTCCCTGGACATGAACTTTTGTAGAAGTAGTTACAATGCTAGTGACCT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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