Basic Information
VIS ID
TVIS44001648
Fusion event
HTLV-1-PHLPP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
60626598/62959365 (Hg38)
End
60626598/62959365 (Hg38)
Orient
-
Location type
Intronic
Target gene
PHLPP1
miRNAs that regulate target gene
hsa-mir-331-3p ; hsa-mir-190a-5p ; hsa-mir-1307-3p ; hsa-mir-877-5p ; hsa-mir-484 ; hsa-mir-17-5p ; hsa-mir-18a-5p ; hsa-mir-19a-3p ; hsa-mir-92a-3p ; hsa-mir-224-5p ; hsa-mir-141-3p ; hsa-mir-1279 ; hsa-mir-4495 ; hsa-mir-15a-5p ; hsa-mir-375 ; hsa-mir-200b-3p ; hsa-mir-7112-3p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-4446-5p ; hsa-mir-3679-3p ; hsa-mir-3127-5p
Nearest miRNA
hsa-mir-1-2/Upstream/4508207; hsa-mir-5011/Downstream/4122219;
Nearest TSS
ENST00000575820/Upstream/53078; ENST00000634673/Downstream/202504;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/242227, chr18-CpG: 236/Downstream/358905
Nearest cancer related gene
PHLPP1(TSG, No orient, 0)
Upstream sequence
aatgttccacaattgaatattacaaagccatttaaaattatttagagctatattgctaactcaaaagatctttacagtatattaagtgaaaatattaata
Downstream sequence
aaattcacaatgaagttttatagtataattcaatttttgcattataaatttgtgtgcattgggtatatgtacatgtgtatgcatacacacatctagaaaa
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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