Basic Information
VIS ID
TVIS44001653
Fusion event
HTLV-1-ASAP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
131413511/130401265 (Hg38)
End
131413511/130401265 (Hg38)
Orient
-
Location type
Intronic
Target gene
ASAP1
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-32-5p ; hsa-mir-106b-5p ; hsa-mir-203a-3p ; hsa-mir-136-5p ; hsa-mir-544a ; hsa-mir-136-3p ; hsa-mir-432-5p ; hsa-mir-493-3p ; hsa-mir-208a-3p ; hsa-mir-208b-3p ; hsa-mir-27b-5p ; hsa-mir-3138 ; hsa-mir-3148 ; hsa-mir-4432 ; hsa-mir-4463 ; hsa-mir-4520-3p ; hsa-mir-4635 ; hsa-mir-4720-3p ; hsa-mir-499a-5p ; hsa-mir-6124 ; hsa-mir-6864-5p ; hsa-mir-8071 ; hsa-mir-8087 ; hsa-mir-875-3p
Nearest miRNA
hsa-mir-1204/Upstream/392812; hsa-mir-10400/Downstream/2645216;
Nearest TSS
ENST00000518652/Upstream/14388; ENST00000523318/Downstream/650;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/42194, chr8-CpG: 141/Downstream/41737
Upstream sequence
gccactgcacccaactgaatgtagaaattcttacttggcaggattgttgggaggagtaaatgaaatTTTATTTTATTGTACTTTTAAtttttatttttga
Downstream sequence
gaaggagtctcactctgttgcccaggctggagtgcaatggtgcaatcttggctcactgcaacctttgcctcctgggttcaagcaattccactgcctcaac
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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