Basic Information
VIS ID
TVIS44001676
Fusion event
HTLV-1-PEX5L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q26.33
Reference genome
GRCh37/hg19
Start
179675529/179957741 (Hg38)
End
179675529/179957741 (Hg38)
Orient
-
Location type
Intronic
Target gene
PEX5L
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-5011-5p ; hsa-mir-101-3p ; hsa-mir-548v ; hsa-mir-139-5p ; hsa-mir-545-5p ; hsa-mir-144-3p ; hsa-mir-548at-5p ; hsa-mir-4282 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-3682-5p ; hsa-mir-190a-3p ; hsa-mir-138-1-3p ; hsa-mir-1277-5p ; hsa-mir-1299 ; hsa-mir-3191-5p ; hsa-mir-642a-5p ; hsa-mir-7106-3p ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-518c-5p ; hsa-mir-6817-3p ; hsa-mir-4469 ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-545-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-4284 ; hsa-mir-6778-3p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-7113-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-4485-5p ; hsa-mir-6890-3p
Nearest miRNA
hsa-let-7g/Upstream/3442590; hsa-mir-1224/Downstream/3929059;
Nearest TSS
ENST00000440867/Upstream/59418; ENST00000464537/Downstream/15511;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/303980, chr3-CpG: 96/Downstream/78991
Upstream sequence
ACAGAAAGCTGCTCAACAAATACTGAAGTGACAGGCTTTCTGGTTTTGTGCCAGGTGTAGAATTTTTCAAATGTGGTGGGTACAGAGGTAATTCTAATGC
Downstream sequence
AAAGTAAGGATTTAATTTATCATACGTAGCACCTCAGACACAAGCACTTGAAACATATGTAGCAACCTCAATGCAATACATGGTTGTTATTGGTTATATT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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