Basic Information
VIS ID
TVIS44001679
Fusion event
HTLV-1-GRHL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
24678560/24352070 (Hg38)
End
24678560/24352070 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
GRHL3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12136/Upstream/422923; hsa-mir-101-1/Downstream/567275;
Nearest TSS
ENST00000473358/Upstream/9910; ENST00000488155/Downstream/27753;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/29386, chr1-CpG: 37/Downstream/61297
Upstream sequence
ATCCACTCTGTTATCCTGCCTCCTGCTTGTTCCTCTAATCACTACGCAATGTGCAAATAAAGGATGCAGCCAGGCTGGCCAGTTTATTTGCCCAGCACCA
Downstream sequence
TAGCCAGGGCATCACTCAGCAGCCCTTCACAGGCACCCCACACACCCCCACGGCCGTGAAAACATCAGCCCCAGGACTGTCTGAAATGTCTGAATGACAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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