Basic Information
VIS ID
TVIS44001684
Fusion event
HTLV-1-TCF12 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
57489893/57197695 (Hg38)
End
57489893/57197695 (Hg38)
Orient
+
Location type
Intronic
Target gene
TCF12
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-26b-5p ; hsa-mir-1224-3p ; hsa-mir-548v ; hsa-mir-33a-3p ; hsa-mir-139-5p ; hsa-mir-8485
Nearest miRNA
hsa-mir-10393/Upstream/1824661; hsa-mir-11181/Downstream/1973488;
Nearest TSS
ENST00000557528/Upstream/63379; ENST00000561235/Downstream/16384;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/277888, chr15-CpG: 58/Downstream/108645
Upstream sequence
CTGTTTTTCACTGGGACTAGTTAAAAGGAATGAAGCCCTCATTACTGTATTTTGCTGCTTACTCCCAAATATTGGAAAACAAGAAAGACGCTAGGGGAAA
Downstream sequence
AGTTATTCTGTTAATTTGAAGTCTTGATTTTTTTCTGGTATATTATGCTGAAGAAATGTATTGTTTTCCATCTGCAGATCCCTTGCAAGCAAAAAAAGTC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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