Basic Information
VIS ID
TVIS44001687
Fusion event
HTLV-1-PRKCE integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
46286333/46059194 (Hg38)
End
46286333/46059194 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
PRKCE
miRNAs that regulate target gene
hsa-mir-205-5p ; hsa-mir-1-3p ; hsa-mir-31-5p ; hsa-mir-96-5p ; hsa-mir-21-5p ; hsa-mir-342-3p ; hsa-mir-107 ; hsa-mir-146a-5p
Nearest miRNA
hsa-mir-1301/Upstream/10587708; hsa-mir-10b/Downstream/1318481;
Nearest TSS
ENST00000437798/Upstream/58292; ENST00000480633/Downstream/14243;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/406648, chr2-CpG: 289/Downstream/237456
Nearest cancer related gene
PRKCE(TSG, No orient, 0)
Upstream sequence
ttaaaaattagctgagctttgtggtgcttgtttgtggtcccagctacttgggaggctgagccatgaggatcactagccatgagcccaggaggttaaggct
Downstream sequence
acagtgagccatgagcccaggaggttaaggctacagtgagccatgatcgcgccgttgcactccagcctggatgacagagtgagaccTCAACCCTTGACCC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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