Basic Information
VIS ID
TVIS44001708
Fusion event
HTLV-1-SHLD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
5814936/5834290 (Hg38)
End
5814936/5834290 (Hg38)
Orient
-
Location type
Intronic
Target gene
SHLD1
miRNAs that regulate target gene
hsa-mir-9-3p ; hsa-mir-6758-3p ; hsa-mir-95-5p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-103a-2/Upstream/1916719; hsa-mir-1-1/Downstream/1537318;
Nearest TSS
ENST00000382410/Upstream/83837; ENST00000488832/Downstream/77140;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/223061, chr20-CpG: 57/Downstream/76942
Upstream sequence
ACTTAGCAGGGAAAAGAGCTCCCTGCCTCCAGGAGAAAGGTTTATGGAAGAGTCTTCCTGCCTTCAGGAGTGGGTTCTCCTATCCTGTGAGTCCTTCTCT
Downstream sequence
TCAAATATAACTTTTCCAAGTTAATTTTTTTGAATAGAGAAATTAGCATGTGTGACTTTTATGCAGAAGAACTTAGGAAAGAGATTATTTATATAATAAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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