Basic Information
VIS ID
TVIS44001721
Fusion event
HTLV-1-PLPPR5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
99388687/98923131 (Hg38)
End
99388687/98923131 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1M
Target gene
PLPPR5
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-101-1/Upstream/876960; hsa-mir-11399/Downstream/1358110;
Nearest TSS
ENST00000473358/Upstream/260908; ENST00000425113/Downstream/81145;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/260976, chr1-CpG: 74/Downstream/81245
Upstream sequence
ATGTGTCAACTAAAAACAAAACAAAACAGTGAATAGGTACCTACATTTCTGGCATCTGGACTTATGCTAATGAACATATGGTGTCAATTGATTGCAGCAA
Downstream sequence
ATGAAATGTCATGAGCCACTACGCTCAAGAATAATTTGGTCCTTCCCCCATCTAATGTATTCTATAGCTCAACTGCTCATAAGTTTATGTATTATTTTAT
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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