Basic Information
VIS ID
TVIS44001722
Fusion event
HTLV-1-MYO3A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
26435416/26146487 (Hg38)
End
26435416/26146487 (Hg38)
Orient
+
Location type
Intronic
Target gene
MYO3A
miRNAs that regulate target gene
hsa-mir-409-3p ; hsa-mir-6894-3p ; hsa-mir-4276 ; hsa-mir-3127-5p ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-138-5p ; hsa-mir-6131 ; hsa-mir-133a-5p ; hsa-mir-4763-5p ; hsa-mir-3692-5p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-3918 ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p
Nearest miRNA
hsa-mir-1265/Upstream/1870706; hsa-mir-107/Downstream/2142771;
Nearest TSS
ENST00000439456/Upstream/194387; ENST00000477691/Downstream/19355;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/211394, chr10-CpG: 40/Downstream/65191
Upstream sequence
cataacaaaaatatcacaggctgcatgacttaaacaacagaaatttatttttttgacagttttggaggcttacagatcaaagtgctctaagtggggttag
Downstream sequence
catctgggaggcctctcttcctggcttgaagatggctaccttctcaaggtgtccccacatggcctttgctatgtgagcatagggagtggggagaaatatc
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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