Basic Information
VIS ID
TVIS44001739
Fusion event
HTLV-1-MITF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p13
Reference genome
GRCh37/hg19
Start
69803240/69754089 (Hg38)
End
69803240/69754089 (Hg38)
Orient
+
Location type
Intronic
Target gene
MITF
miRNAs that regulate target gene
hsa-mir-96-5p ; hsa-mir-182-5p ; hsa-mir-137 ; hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-mir-218-5p ; hsa-mir-675-5p ; hsa-mir-101-3p ; hsa-mir-2113 ; hsa-mir-147b ; hsa-mir-210-3p ; hsa-mir-6828-5p ; hsa-mir-574-5p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-4711-3p ; hsa-mir-3679-3p ; hsa-mir-513a-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6830-5p ; hsa-mir-4762-5p ; hsa-mir-224-5p ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-mir-216a-5p ; hsa-mir-340-5p
Nearest miRNA
hsa-let-7g/Upstream/705054; hsa-mir-12124/Downstream/1787881;
Nearest TSS
ENST00000440867/Upstream/14607; ENST00000457080/Downstream/4615;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/14032, chr3-CpG: 50/Downstream/1311094
Nearest cancer related gene
MITF(OG, No orient, 0)
Upstream sequence
atatgtgatttgggggaccaggggtagaatgatatggtttgaatctgtgtccccaccaaatctcaggtcaaattgtaatccccaatgttgcaggtgaggc
Downstream sequence
ctgatgggaggtgatttggatcatggaagtggtttctcatgaatggtttagcaacacccacttagtgctgttcttgtgatagtgagtgattcttatgagt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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