Basic Information
VIS ID
TVIS44001741
Fusion event
HTLV-1-SEPTIN11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
77958312/77037159 (Hg38)
End
77958312/77037159 (Hg38)
Orient
+
Location type
UTR3
Target gene
SEPTIN11
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-186-5p ; hsa-mir-101-3p ; hsa-mir-222-3p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12113/Upstream/461533; hsa-mir-1243/Downstream/5716178;
Nearest TSS
ENST00000502981/Upstream/2235; ENST00000512918/Downstream/18890;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/86190, chr4-CpG: 106/Downstream/38109
Upstream sequence
AATCCGAAATTACTAATCCAggccaggtgtggtggctcatgcctgtaatcccagcactttgagaggccgaggtgggcagatcacttgaggcctggagttc
Downstream sequence
aagaccaccttggcgaacacggtgaaaccccgtctctacaaaaaatacaaaaattagccaggcgtggtggcacgtgcctgtagtcccagctacttgggag
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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