VISDB - VIS Detail

Basic Information

VIS ID

TVIS44001744

Fusion event

HTLV-1-HAPLN1 integration

Validated

No

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2017

PubMed ID

28811663

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr5

Cytoband

q14.3

Reference genome

GRCh37/hg19

Start

82935754/83639935 (Hg38)

End

82935754/83639935 (Hg38)

Orient

+

Location type

UTR3

Target gene

HAPLN1

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-4668-5p ; hsa-mir-3978 ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-4717-3p ; hsa-mir-130a-5p ; hsa-mir-23b-3p ; hsa-mir-23c ; hsa-mir-23a-3p ; hsa-mir-129-5p ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-3714 ; hsa-mir-548an ; hsa-mir-5587-5p ; hsa-mir-6801-5p

Nearest miRNA

hsa-mir-10397/Upstream/799711; hsa-mir-103a-1/Downstream/3474944;

Nearest TSS

ENST00000502646/Upstream/58615; ENST00000507060/Downstream/33609;

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/165155, chr5-CpG: 59/Downstream/82140

Upstream sequence

GGACCTACTTTTATTACAATATTTTGTCTGAATAATATATGATTATAGTTATGGTTTCATGGACTTCCAATTGTTCTATACCTTCCACACACAGAACTCT

Downstream sequence

ATAGAGTAAATTTATTAGAATTATTACAGAGCTTTAAATGCAACCACAATCCATTCAGGAAACAGATTTATTTACTCATGTTCATGGGAGGAAAATCTAC

Reference

Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.