Basic Information
VIS ID
TVIS44001760
Fusion event
HTLV-1-ITM2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
48826939/48252803 (Hg38)
End
48826939/48252803 (Hg38)
Orient
-
Location type
Intronic
Target gene
ITM2B
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-186-5p ; hsa-mir-100-5p ; hsa-mir-99a-5p ; hsa-mir-25-3p ; hsa-let-7a-5p ; hsa-mir-95-5p ; hsa-mir-670-3p
Nearest miRNA
hsa-mir-2276/Upstream/4056603; hsa-mir-1267/Downstream/1743612;
Nearest TSS
ENST00000623511/Upstream/19600; ENST00000607866/Downstream/1072;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/18991, chr13-CpG: 106/Downstream/50520
Upstream sequence
TAGGTTTAGGTGAAGTCTGCTTTCTGCCTTAAGCCTACTCCATAGTGGGTTTTCCAAGTAAAGGACAGAGTCATGTACTTCAAAGAGGCTGTTCATGTAT
Downstream sequence
ACTATGAATTTTTGCAGTCTTTACTATTTATTGAGTGACTACTTATTTAAGTATCTTTGTTTTCTTAGCTCTTTGCACATGAACTTGGGTACAAATCAGA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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