Basic Information
VIS ID
TVIS44001763
Fusion event
HTLV-1-PPP1R3E integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
23765774/23296565 (Hg38)
End
23765774/23296565 (Hg38)
Orient
-
Location type
UTR3
Target gene
PPP1R3E
miRNAs that regulate target gene
hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6873-3p ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-6868-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-627-3p ; hsa-mir-942-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-5197-3p
Nearest miRNA
hsa-mir-4707/Upstream/339536; hsa-mir-1185-1/Downstream/92031;
Nearest TSS
ENST00000550708/Upstream/10448; ENST00000553824/Downstream/302;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/10318, chr14-CpG: 153/Downstream/4738
Upstream sequence
cagcttcctgagtagctgggaatacagatgtgtgccaccatgcccagctaattttaaaagtttttgtagagacagggtcccactatgttgctcagactgg
Downstream sequence
tctcgaactcctgggctcaagcaatgctcctgcctcagcctcccaaagtgttgcgattacaggtatgaaccaccacaccGAGCAGAGACCTGTTTCCTAG
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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