Basic Information
VIS ID
TVIS44001777
Fusion event
HTLV-1-GAS7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
10013863/10110546 (Hg38)
End
10013863/10110546 (Hg38)
Orient
-
Location type
Intronic
Target gene
GAS7
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-1255b-5p ; hsa-mir-6744-5p ; hsa-mir-1255a ; hsa-mir-1287-5p ; hsa-mir-4487 ; hsa-mir-450b-5p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-3124-3p ; hsa-mir-6837-3p
Nearest miRNA
hsa-mir-1253/Upstream/1923542; hsa-mir-10226/Downstream/1971353;
Nearest TSS
ENST00000595228/Upstream/49167; ENST00000609088/Downstream/4007;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/205524, chr17-CpG: 142/Downstream/87171
Upstream sequence
agttagacagaagatataagttcttttctttttttttaagacggagtctcgctgtgacacccaggctgaagtgcaatggcgcaatcttggctcacggcaa
Downstream sequence
cctccgtctcccgggttcaaccaattctcctgtctaagcctcagcctcccaagtagttgggactacaggtgcatgtcaccacgtctggctgatttttgta
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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