Basic Information
VIS ID
TVIS44001784
Fusion event
HTLV-1-RALGAPA2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
20412577/20431933 (Hg38)
End
20412577/20431933 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA20A
Target gene
RALGAPA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-let-7c-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-491-5p ; hsa-mir-6825-5p ; hsa-mir-92a-2-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-3616-3p ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-627-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/1961242; hsa-mir-1-1/Downstream/5776253;
Nearest TSS
ENST00000382410/Upstream/63812; ENST00000432942/Downstream/80667;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/61972, chr20-CpG: 17/Downstream/20528
Upstream sequence
ATGTCACTTCTATAGCATGTGTGCACCTCTCTATGCAGCCATAATGTCTACAAGAGGCCTGTGTCCCGGGTTTTTCCTCTATGCAAAGTTGAAGTAGGGG
Downstream sequence
CTATCTTCAATGAGAAACATCCACTAATATTACTTGCACAGACTTAATGGGAGAGATAAATGGGTTATACATCAGTTAACTTGTAACTAATAATAAATTA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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