Basic Information
VIS ID
TVIS44001791
Fusion event
HTLV-1-NEK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q33
Reference genome
GRCh37/hg19
Start
170464477/169543326 (Hg38)
End
170464477/169543326 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEK1
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-484 ; hsa-mir-302a-5p ; hsa-mir-6507-3p
Nearest miRNA
hsa-mir-12113/Upstream/4156989; hsa-mir-1305/Downstream/1642858;
Nearest TSS
ENST00000502981/Upstream/36592; ENST00000506924/Downstream/42173;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/271633, chr4-CpG: 55/Downstream/68921
Upstream sequence
ccatttattaaatagggaatcctttccccaccacttgtttatcgggtttgttaaagagcagatggttgtagatgtgtggcattatttctaaggcctctgt
Downstream sequence
tctgttccattggtctatatatctgttttggtaccagtaccatgctgttttggttaccgtacccttgtagtatagtttgaagtcaggtagcaggatgcct
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate