Basic Information
VIS ID
TVIS44001795
Fusion event
HTLV-1-EVC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
5639758/5638031 (Hg38)
End
5639758/5638031 (Hg38)
Orient
-
Location type
Intronic
Target gene
EVC2
miRNAs that regulate target gene
hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-3942-3p ; hsa-mir-6873-3p ; hsa-mir-5100 ; hsa-mir-4722-5p ; hsa-mir-6721-5p ; hsa-mir-942-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-5088-3p ; hsa-mir-6729-3p ; hsa-mir-4768-3p ; hsa-mir-1245b-3p ; hsa-mir-6866-3p ; hsa-mir-188-5p
Nearest miRNA
hsa-mir-4800/Upstream/3387875; hsa-mir-12113/Downstream/285244;
Nearest TSS
ENST00000502981/Upstream/200114; ENST00000514919/Downstream/70536;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/69407, chr4-CpG: 56/Downstream/70227
Upstream sequence
atttgatttttaaaactctttaaaaatgtaaaaaaacattctcaacttgcaggccacataaaaacaagctgggtaagattgggctcatgggtccttgttt
Downstream sequence
gctgaccactgCCTTAAGGTACTGTCGAAGCCTCCCTTATTGAGCATGTATTACGTTTAAAGGTAAAAAAAAATTggccatgcgtggtggctcatgcctg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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