Basic Information
VIS ID
TVIS44001818
Fusion event
HTLV-1-MACO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
25781383/25454892 (Hg38)
End
25781383/25454892 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MACO1
miRNAs that regulate target gene
hsa-mir-4446-5p ; hsa-mir-3679-3p ; hsa-mir-6832-3p ; hsa-mir-627-3p
Nearest miRNA
hsa-mir-12136/Upstream/431306; hsa-mir-101-1/Downstream/451470;
Nearest TSS
ENST00000473358/Upstream/5999; ENST00000485476/Downstream/88688;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/23268, chr1-CpG: 109/Downstream/88510
Upstream sequence
TATTCTTTGTCTATAATTCATTTCACTGTAGAATGTTAAGTTCAACTGTAAATTTATTCTTAGAAATTTTACATGGATCCAGAAAGCAGTAcagcatggt
Downstream sequence
tggaaagaccatgagcccccccttttcaggcagatgagtgaatcccagctctgtcctctgacagcttgtgttgccttgtcactgcctctaagccatggtt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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