Basic Information
VIS ID
TVIS44001845
Fusion event
HTLV-1-STT3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p23
Reference genome
GRCh37/hg19
Start
31659292/31617800 (Hg38)
End
31659292/31617800 (Hg38)
Orient
+
Location type
Intronic
Target gene
STT3B
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-23a-3p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-12127/Upstream/456013; hsa-let-7g/Downstream/888483;
Nearest TSS
ENST00000440867/Upstream/20994; ENST00000488151/Downstream/8261;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/84010, chr3-CpG: 104/Downstream/362677
Upstream sequence
CTTTATCTCAAATGTGTTTCTCTGGAAGTGGGTTCTCCATGGATATTGTTTTTATTTGATCACTACCTTATTTTTTCTGACTGCCAACTGTCTGAAATAG
Downstream sequence
GTTGACACCTATAAATGAAAACTGAAATTCTTTGAACATTAGTTTGTCTATCTATAATTAGCAATAAACATAAAGGCAATAAAAGATTTACAAAATAATA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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