Basic Information
VIS ID
TVIS44001848
Fusion event
HTLV-1-METTL6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
15441809/15400302 (Hg38)
End
15441809/15400302 (Hg38)
Orient
+
Location type
Intronic
Target gene
METTL6
miRNAs that regulate target gene
hsa-let-7a-5p ; hsa-mir-7109-5p ; hsa-mir-6085 ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-6824-5p ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-6870-5p ; hsa-mir-7111-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-3175 ; hsa-mir-7106-5p ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-765 ; hsa-mir-4784 ; hsa-mir-4731-5p ; hsa-mir-3150b-3p ; hsa-mir-637 ; hsa-mir-6783-5p
Nearest miRNA
hsa-mir-12127/Upstream/5005740; hsa-let-7g/Downstream/95937;
Nearest TSS
ENST00000440867/Upstream/811; ENST00000449565/Downstream/15558;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/67600, chr3-CpG: 46/Downstream/27123
Nearby gene
METTL6(-9458) ;
Upstream sequence
aatttgtgccgtgacctcctctccgcacccccaccaagtgcagcaccagatgtaccctctccacaccctctctgcacccccaccaagccccaggtcccct
Downstream sequence
attcctttccatggcctcaagatggtacacacactggctcttctgggagtttcatattttgtgaggcctccatgcatatgtgcacataataaatttgtgt
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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