Basic Information
VIS ID
TVIS44001851
Fusion event
HTLV-1-GPM6A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q34.2
Reference genome
GRCh37/hg19
Start
176656152/175735001 (Hg38)
End
176656152/175735001 (Hg38)
Orient
+
Location type
Intronic
Target gene
GPM6A
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-218-5p ; hsa-mir-17-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-12113/Upstream/1311137; hsa-mir-1305/Downstream/6434292;
Nearest TSS
ENST00000502981/Upstream/80678; ENST00000514864/Downstream/52386;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/905568, chr4-CpG: 26/Downstream/266321
Nearest cancer related gene
GPM6A(OG, No orient, 0)
Upstream sequence
TTTGAGCCCTTTTATACCCTTGAGAATGACTTATTTATAAGAACCCTCCACACTACAAGTGTTTTCCAATAAGACAATGAACAATTATTGAATGCTTACT
Downstream sequence
TTATAAATGTCATGAAACCATATTTGTCTTTGTTCAGAACAGTGCTTTATATTGTATATTTTATATGTGGCATTTGGTGCAACTTATAATAGTTTTCAAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
Curate