Basic Information
VIS ID
TVIS44001863
Fusion event
HTLV-1-SEMA3C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
80543639/80914323 (Hg38)
End
80543639/80914323 (Hg38)
Orient
+
Location type
Intronic
Target gene
SEMA3C
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-375 ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-10525/Upstream/4999054; hsa-mir-10399/Downstream/11289692;
Nearest TSS
ENST00000635602/Upstream/95914; ENST00000431501/Downstream/4106;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/778750, chr7-CpG: 59/Downstream/4667
Upstream sequence
ATTTAAATATATACTCTTAAATACATTAACCCCATACAAAGCTCTATATTTTGATGTTGAGAATAAACTACTTTGGAGGAAACTTAAAAACCTACTTGGT
Downstream sequence
ACAATAGTCAATGAGTCATCATTTGACTAATGAGAAACTTTAAATAATAATAAATTTGAACAGGCATTTCAAGCAGGTACACTGTGAAATCTCCTAAGAA
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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