Basic Information
VIS ID
TVIS44001892
Fusion event
HTLV-1-MAML2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh37/hg19
Start
95806184/96073020 (Hg38)
End
95806184/96073020 (Hg38)
Orient
-
Location type
Intronic
Target gene
MAML2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-218-5p ; hsa-mir-6868-3p ; hsa-mir-6715b-3p ; hsa-mir-3605-3p ; hsa-mir-205-5p
Nearest miRNA
hsa-mir-10392/Upstream/1606440; hsa-let-7a-2/Downstream/268418;
Nearest TSS
ENST00000527297/Upstream/147705; ENST00000332349/Downstream/20500;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/148819, chr11-CpG: 75/Downstream/316352
Nearest cancer related gene
MAML2(OG, No orient, 0)
Upstream sequence
TTTCAGTTAAGTACTTTTAGACCTCAGTCCAAACCCCTTCTCTTAGGATTTGGCTCAAACTATTGATAATCATAAATTTCCATATTTATATTTCCAATCT
Downstream sequence
GTGAGGACTTAAAAAAACTATTATGGAAACCAAGTACAATCTTAGGGAACAGACTGTGTATTTAATTTACACAATGAAACTTGGGCTGTAGCATTAATAC
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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