Basic Information
VIS ID
TVIS44001902
Fusion event
HTLV-1-PLGRKT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
5367181/5367181 (Hg38)
End
5367181/5367181 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLGRKT
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4326 ; hsa-mir-3682-5p ; hsa-mir-4778-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-4255 ; hsa-mir-607 ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-3671 ; hsa-mir-6879-3p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-6872-3p ; hsa-mir-4277 ; hsa-mir-584-3p ; hsa-mir-1306-5p ; hsa-mir-7853-5p ; hsa-mir-105-5p ; hsa-mir-513b-3p
Nearest miRNA
hsa-mir-101-2/Upstream/516806; hsa-let-7a-1/Downstream/640645;
Nearest TSS
ENST00000422679/Upstream/14771; ENST00000474218/Downstream/69513;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/27503, chr9-CpG: 43/Downstream/70385
Upstream sequence
agaaatcagagacagcacaaacaaatgaaagaacattccacgctcatgaattggaagaatcaatatcattaaaatggccatactgcccaaagtaaaatac
Downstream sequence
agattaagtgctattcctatcaaactaccaacatcattcttcacagaactagaaaaaaaacttttctaaaattcatatgaaaccaaaaaaagtccaaata
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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