Basic Information
VIS ID
TVIS44001917
Fusion event
HTLV-1-SIMC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
175734122/176307119 (Hg38)
End
175734122/176307119 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
SIMC1
miRNAs that regulate target gene
hsa-mir-1226-3p
Nearest miRNA
hsa-mir-10397/Upstream/1555332; hsa-mir-1229/Downstream/60827;
Nearest TSS
ENST00000502646/Upstream/10996; ENST00000332772/Downstream/5961;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/68095, chr5-CpG: 58/Downstream/54199
Upstream sequence
tgatatggaaatggccaacaaacttctgaaaagatactcaatataactagttattagaggtatgcaaatcaaaaccacaatgcaatgtcacctcatacca
Downstream sequence
attagaatggccactattttttaaaaaaacaaaaaataagtgtgggcaagaatttggagaaattagaacctttgtgcactcttgggattgtaaagtggtg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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