Basic Information
VIS ID
TVIS44001919
Fusion event
HTLV-1-SLC15A4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
129305540/128820995 (Hg38)
End
129305540/128820995 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
SLC15A4
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-151a-5p ; hsa-mir-186-5p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-4668-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-let-7i/Upstream/526817; hsa-mir-6763/Downstream/3761002;
Nearest TSS
ENST00000382841/Upstream/1128; ENST00000611714/Downstream/2527;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/25054, chr12-CpG: 75/Downstream/2394
Upstream sequence
cagtgcttctcgtggggcctagtgtttgggtcatggggacggatccctgaagaaaggcttggggctgtcacaggagtgaactctcctatgagagaggtcg
Downstream sequence
tttacaagcctggcacctccctcccctctctcacttcctctagtgcatgtgatctctacacagctggctcccattcacaaggccctcagcagtgcagatg
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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