Basic Information
VIS ID
TVIS44001932
Fusion event
HTLV-1-MYSM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2017
PubMed ID
28811663
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p32.1
Reference genome
GRCh37/hg19
Start
59134815/58669143 (Hg38)
End
59134815/58669143 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
MYSM1
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-186-5p ; hsa-mir-8485 ; hsa-mir-376b-3p ; hsa-mir-376a-3p
Nearest miRNA
hsa-mir-12136/Upstream/3443420; hsa-mir-101-1/Downstream/1064084;
Nearest TSS
ENST00000473358/Upstream/660; ENST00000637377/Downstream/12753;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/91520, chr1-CpG: 271/Downstream/112646
Upstream sequence
AAAGAAAAAAAATTTTCAATACAATCTCAACAAGATTAGGAAAATAACATTTATTTGTAAATCTGAAAGTGTATATCAATAATCTAAACCCAAATTCTGT
Downstream sequence
CTAAATGAGAGAGTTTTGTAGGAAATTCCATAAACCCTTTCGAAAGAAGCACTGTTCTTTTAGATTTAACAAGAACAAAAAAAAAACCCaggaactttga
Reference
Artesi, M., et al.Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia ,2017,31(11): 2532-2535.
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